Interaction of Amphetamines and Related Compounds at the Vesicular Monoamine Transporter

@article{Partilla2006InteractionOA,
  title={Interaction of Amphetamines and Related Compounds at the Vesicular Monoamine Transporter},
  author={J. Partilla and Allison G. Dempsey and A. Nagpal and B. Blough and M. Baumann and R. Rothman},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={319},
  pages={237 - 246}
}
Amphetamine-type agents interact with the vesicular monoamine transporter type 2 (VMAT2), promoting the release of intravesicular neurotransmitter and an increase in cytoplasmic neurotransmitter. Some compounds, such as reserpine, “release” neurotransmitter by inhibiting the ability of VMAT2 to accumulate neurotransmitter in the vesicle, whereas other types of compounds can release neurotransmitter via a carrier-mediated exchange mechanism. The purpose of this study was to determine, for 42… Expand
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