Interaction of Amineptine with Agents Modifying Dopaminergic Transmission

  title={Interaction of Amineptine with Agents Modifying Dopaminergic Transmission},
  author={Abdeslam Chagraoui and Marc Vasse and Philippe Protais},
  journal={Clinical Neuropharmacology},
Summary: Amineptine, administered at increasing doses (5‐40 mg/kg, i.p.) in mice, induces a dose‐dependent hyperactivity (measured either in classical activity cages or in a DIGISCAN actimeter) which persists for about 8 h at 20 mg/kg. The increase of locomotor activity induced by 20 mg/kg amineptine is dose‐dependently antagonized by metoclopramide (1.25‐120 mg/kg i.p.), by SCH 23390 (7.5‐8,000 &mgr;g/kg s.c.) and by amisulpride (1.56‐50 mg/kg i.p.). Nevertheless, whereas the increase of… Expand
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