Interaction of Afobazole with σ1-Receptors

  title={Interaction of Afobazole with σ1-Receptors},
  author={S. Seredenin and T. Antipova and M. Voronin and S. Kurchashova and A. Kuimov},
  journal={Bulletin of Experimental Biology and Medicine},
  • S. Seredenin, T. Antipova, +2 authors A. Kuimov
  • Published 2009
  • Biology
  • Bulletin of Experimental Biology and Medicine
  • In vitro radioligand assay revealed interaction of afobazole with σ1-receptors (Ki=5.9 × 10—6 M). Translocation of σ1-receptors from the endoplasmic reticulum to the outer membrane was demonstrated by confocal microscopy. Experiments were performed on the model of HT-22 immortalized hippocampal cells after incubation with afobazole in a concentration of 10—8 M. 

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