Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis.

@article{Shibasaki2004InteractionOA,
  title={Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis.},
  author={Tadao Shibasaki and Yasuhiro Sunaga and Kei Fujimoto and Yasushige Kashima and Susumu Seino},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 9},
  pages={7956-61}
}
ATP, cAMP, and Ca(2+) are the major signals in the regulation of insulin granule exocytosis in pancreatic beta cells. The sensors and regulators of these signals have been characterized individually. The ATP-sensitive K(+) channel, acting as the ATP sensor, couples cell metabolism to membrane potential. cAMP-GEFII, acting as a cAMP sensor, mediates cAMP-dependent, protein kinase A-independent exocytosis, which requires interaction with both Piccolo as a Ca(2+) sensor and Rim2 as a Rab3 effector… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 68 extracted citations

Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.

Progress in biophysics and molecular biology • 2011
View 5 Excerpts
Highly Influenced

Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells.

American journal of physiology. Endocrinology and metabolism • 2009
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…