Interaction of APC/C-E3 ligase with Swi6/HP1 and Clr4/Suv39 in heterochromatin assembly in fission yeast.

@article{Dubey2009InteractionOA,
  title={Interaction of APC/C-E3 ligase with Swi6/HP1 and Clr4/Suv39 in heterochromatin assembly in fission yeast.},
  author={Rudra Narayan Dubey and Nandni Nakwal and Kamlesh Kumar Bisht and Ashok Kumar Saini and Swati Haldar and Jagmohan Singh},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 11},
  pages={7165-76}
}
Heterochromatin assembly in fission yeast is initiated by binding of Swi6/HP1 to the Lys-9-dimethylated H3 followed by spreading via cooperative recruitment of Swi6/HP1. Recruitment of Cohesin by Swi6/HP1 further stabilizes the heterochromatin structure and integrity. Subsequently, polyubiquitylation of Cut2 by anaphase-promoting complex-cyclosome (APC/C)-ubiquitin-protein isopeptide ligase (E3 ligase) followed by degradation of Cut2 releases Cut1, which cleaves the Rad21 subunit of Cohesin… CONTINUE READING