Corpus ID: 83039811

Interaction of A beta peptide (1-40) with amino acid aluminium complexes: relevance to Alzheimer's disease

@inproceedings{Ramesh1999InteractionOA,
  title={Interaction of A beta peptide (1-40) with amino acid aluminium complexes: relevance to Alzheimer's disease},
  author={J. Ramesh and T. Madhav and S. Vatsala and T. Ramakrishna and K. Easwaran and O. Guillard and R. Deloncle},
  year={1999}
}
A beta (39-43 aminoacid residues) is the principal peptide component of amyloid deposits in Alzheimer's disease (AD). A beta peptide is derived from the amyloid precursor protein (APP) in which mutations give rise to many forms of familial AD. Aluminium is reported to play a key role in inducing conformational change in the synthetic beta-amyloid peptide (1-40)from alpha-helix to beta-pleated sheet, leading to aggregation and fibrillar formation. We have studied the interaction of amino acid-Al… Expand