Interaction of 99mTc-labeled liposomes with Walker tumour cells in vitro. Liposome-mediated introduction of thaliblastine into resistant Walker tumour cells.


A method for labeling phospholipid vesicles (liposomes) with 99mTc-pertechnetate is described. The labeling methodology involves the chemical reduction of sodium 99mTc-pertechnetate by stannous chloride, which produces a 99mTc-SnCl2 complex with high binding capacity to phospholipids. Binding studies in vitro showed that Walker tumour cells can incorporate… (More)


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