Interaction of 4-Dimethylaminoazobenzene and Dietary Fat in the Regulation of Hepatic Microsomal Ascorbic Acid Synthesis

@article{Ray1965InteractionO4,
  title={Interaction of 4-Dimethylaminoazobenzene and Dietary Fat in the Regulation of Hepatic Microsomal Ascorbic Acid Synthesis},
  author={S. C. Ray and R. J. Morin},
  journal={Nature},
  year={1965},
  volume={207},
  pages={1294-1295}
}
AN increase in urinary ascorbic acid excretion in rats has been demonstrated to occur after an injection of 4-dimethylaminoazobenzene (DAB) and also after the injection of several methylated derivatives of this carcinogen1. Other types of compounds, such as chloretone, aminopyrine, meprobamate and phenylbutazone, also increase the urinary excretion of ascorbic acid in rats2,3. It has been suggested that these compounds stimulate the biosynthesis of glucuronic acid as an adaptive response for… CONTINUE READING