Interaction of 3-alkylpyridinium polymers from the sea sponge Reniera sarai with insect acetylcholinesterase.

@article{Sepi1999InteractionO3,
  title={Interaction of 3-alkylpyridinium polymers from the sea sponge Reniera sarai with insect acetylcholinesterase.},
  author={Kristina Sep{\vc}i{\vc} and N Poklar and Gorazd Vesnaver and Didier Fournier and Tom Turk and Peter Ma{\vc}ek},
  journal={Journal of protein chemistry},
  year={1999},
  volume={18 3},
  pages={251-7}
}
3-Alkylpyridinium polymers (poly-APS), composed of 29 or 99 N-butyl-3-butyl pyridinium units, were isolated from the marine sponge Reniera sarai. They act as potent cholinesterase inhibitors. The inhibition kinetics pattern reveals several successive phases ending in irreversible inhibition of the enzyme. To provide more information on mechanism of inhibition, interaction of poly-APS and N-butyl-3-butyl pyridinium iodide (NBPI) with soluble dimeric and monomeric insect acetylcholinesterase… CONTINUE READING