Interaction of Δ9‐tetrahydrocannabinol and cannabidiol with phenobarbitone in protecting mice from electrically induced convulsions

@article{Chesher1975InteractionO,
  title={Interaction of $\Delta$9‐tetrahydrocannabinol and cannabidiol with phenobarbitone in protecting mice from electrically induced convulsions},
  author={Gregory B. Chesher and David M. Jackson and Ron Malor},
  journal={Journal of Pharmacy and Pharmacology},
  year={1975},
  volume={27}
}
In a previous study (Chesher & Jackson, 1974) we reported that the protection against electrically-induced seizures afforded mice by phenytoin, was potentiated significantly by Ag-tetrahydrocannabinol (THC) and cannabidiol (CBD). In contrast, these cannabinoids failed to alter the effect of phenobarbitone on the convulsive threshold to leptazol induced seizures. Although TMC itself showed a weak anticonvulsant activity against electrically induced seizures, it failed to affect the convulsive… 

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