Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae

@article{Babu2012InteractionLO,
  title={Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae},
  author={M. Babu and James Vlasblom and S. Pu and Xinghua Guo and Chris Graham and B. Bean and Helen E. Burston and F. Vizeacoumar and J. Snider and S. Phanse and Vincent Fong and Y. Y. Tam and Michael Davey and Olha Hnatshak and Navgeet Bajaj and Shamanta Chandran and Thanuja Punna and Constantine Christopolous and V. Wong and A. Yu and Gouqing Zhong and Joyce Li and I. Stagljar and E. Conibear and S. Wodak and A. Emili and J. Greenblatt},
  journal={Nature},
  year={2012},
  volume={489},
  pages={585-589}
}
Macromolecular assemblies involving membrane proteins (MPs) serve vital biological roles and are prime drug targets in a variety of diseases. Large-scale affinity purification studies of soluble-protein complexes have been accomplished for diverse model organisms, but no global characterization of MP-complex membership has been described so far. Here we report a complete survey of 1,590 putative integral, peripheral and lipid-anchored MPs from Saccharomyces cerevisiae, which were affinity… Expand
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