Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk.

  title={Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk.},
  author={Mark T W Ebbert and Kevin L. Boehme and Mark E. Wadsworth and Lyndsay A. Staley and Shubhabrata Mukherjee and Paul K Crane and Perry G. Ridge and John S K Kauwe},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  volume={12 2},
INTRODUCTION Ebbert et al. reported gene-gene interactions between rs11136000-rs670139 (CLU-MS4A4E) and rs3865444-rs670139 (CD33-MS4A4E). We evaluate these interactions in the largest data set for an epistasis study. METHODS We tested interactions using 3837 cases and 4145 controls from Alzheimer's Disease Genetics Consortium using meta-analyses and permutation analyses. We repeated meta-analyses stratified by apolipoprotein E (APOE) ε4 status, estimated combined odds ratio (OR) and… CONTINUE READING

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