Interaction between tumor necrosis factor microsatellite polymorphisms and the HLA-DRB1 shared epitope in rheumatoid arthritis: influence on disease outcome.

@article{Mattey1999InteractionBT,
  title={Interaction between tumor necrosis factor microsatellite polymorphisms and the HLA-DRB1 shared epitope in rheumatoid arthritis: influence on disease outcome.},
  author={Derek L. Mattey and Andrew B. Hassell and Peter T Dawes and William E. R. Ollier and A H Hajeer},
  journal={Arthritis and rheumatism},
  year={1999},
  volume={42 12},
  pages={2698-704}
}
OBJECTIVE To investigate whether interactions between tumor necrosis factor (TNF) microsatellite polymorphisms and the HLA-DRB1 shared epitope (SE) are associated with disease severity in rheumatoid arthritis (RA), and to determine if such associations are the same in male and female patients. METHODS Genotyping for the TNFa microsatellite and HLA-DRB1 was carried out on 157 RA patients with established disease (duration >5 years). Disease severity measures included radiographic damage (the… CONTINUE READING
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