Interaction between the opposing functional effects of cyclic AMP and cyclic GMP in hypertrophic cardiac myocytes

@article{Patel2001InteractionBT,
  title={Interaction between the opposing functional effects of cyclic AMP and cyclic GMP in hypertrophic cardiac myocytes},
  author={Kepal Narendra Patel and Lin Yan and Ankur Navinchandra Gandhi and Peter M. Scholz and Harvey R. Weiss},
  journal={Basic Research in Cardiology},
  year={2001},
  volume={96},
  pages={34-41}
}
We tested the hypothesis that in isolated cardiac myocytes, the negative functional effects of cyclic GMP would be blunted when the level of cyclic AMP was increased and that this interaction would be altered in renal hypertensive (One-Kidney-One-Clip, 1K1C) cardiac hypertrophic rabbits. Using isolated control and 1K1C ventricular myocytes, cyclic AMP and cell shortening (%) data were collected: 1) at baseline, 2) after the addition of 8-Br-cGMP 10−7, −6, −5 M, and 3) after forskolin (10−6 M… CONTINUE READING

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