Interaction between the immunoglobulin heavy chain 3' regulatory region and the IgH transcription unit during B cell differentiation.

@article{Ju2011InteractionBT,
  title={Interaction between the immunoglobulin heavy chain 3' regulatory region and the IgH transcription unit during B cell differentiation.},
  author={Zhongliang Ju and Sanjukta Chatterjee and Barbara K. Birshtein},
  journal={Molecular immunology},
  year={2011},
  volume={49 1-2},
  pages={297-303}
}
The immunoglobulin heavy (Igh) chain locus is subject to precisely regulated processes, such as variable region gene formation through recombination of variable (V(H)), diversity (D(H)), and joining (J(H)) segments, class switching and somatic hypermutation. The 3' regulatory region (3' RR) is a key regulator of the Igh locus, and, as revealed by deletions in mouse plasma cell lines and mice, is required for IgH expression as well as class switching. One of the mechanisms by which the 3' RR… CONTINUE READING
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