Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.

@article{Suhasini2011InteractionBT,
  title={Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.},
  author={Avvaru N. Suhasini and Nina A Rawtani and Yuliang Wu and Joshua A. Sommers and Sudha Sharma and Georgina Mosedale and Phillip S. North and Sharon B Cantor and Ian D. Hickson and Robert M. Brosh},
  journal={The EMBO journal},
  year={2011},
  volume={30 4},
  pages={692-705}
}
Bloom's syndrome (BS) and Fanconi anemia (FA) are autosomal recessive disorders characterized by cancer and chromosomal instability. BS and FA group J arise from mutations in the BLM and FANCJ genes, respectively, which encode DNA helicases. In this work, FANCJ and BLM were found to interact physically and functionally in human cells and co-localize to nuclear foci in response to replication stress. The cellular level of BLM is strongly dependent upon FANCJ, and BLM is degraded by a proteasome… CONTINUE READING