Interaction between the Triglyceride Lipase ATGL and the Arf1 Activator GBF1

  title={Interaction between the Triglyceride Lipase ATGL and the Arf1 Activator GBF1},
  author={Emy Njoh Ellong and Krishnakant G. Soni and Q Bui and Rachid Sougrat and Marie-Pierre Golinelli-Cohen and Catherine L Jackson},
  booktitle={PloS one},
The Arf1 exchange factor GBF1 (Golgi Brefeldin A resistance factor 1) and its effector COPI are required for delivery of ATGL (adipose triglyceride lipase) to lipid droplets (LDs). Using yeast two hybrid, co-immunoprecipitation in mammalian cells and direct protein binding approaches, we report here that GBF1 and ATGL interact directly and in cells, through multiple contact sites on each protein. The C-terminal region of ATGL interacts with N-terminal domains of GBF1, including the catalytic… CONTINUE READING
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