Interaction between the SifA virulence factor and its host target SKIP is essential for Salmonella pathogenesis.

  title={Interaction between the SifA virulence factor and its host target SKIP is essential for Salmonella pathogenesis.},
  author={Lautaro Diacovich and Audrey Dumont and Daniel Lafitte and Elodie Soprano and Aude-Agn{\`e}s Guilhon and Christophe Bignon and Jean-Pierre E. Gorvel and Yves Bourne and St{\'e}phane M{\'e}resse},
  journal={The Journal of biological chemistry},
  volume={284 48},
SifA is a Salmonella effector that is translocated into infected cells by the pathogenicity island 2-encoded type 3 secretion system. SifA is a critical virulence factor. Previous studies demonstrated that, upon translocation, SifA binds the pleckstrin homology motif of the eukaryotic host protein SKIP. In turn, the SifA-SKIP complex regulates the mobilization of the molecular motor kinesin-1 on the bacterial vacuole. SifA exhibits multiple domains containing functional motifs. Here we… CONTINUE READING


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