Interaction between the Rev 1 C-Terminal Domain and the PolD 3 Subunit of Pol Suggests a Mechanism of Polymerase Exchange upon Rev 1 / Pol-Dependent

@inproceedings{Pustovalova2016InteractionBT,
  title={Interaction between the Rev 1 C-Terminal Domain and the PolD 3 Subunit of Pol Suggests a Mechanism of Polymerase Exchange upon Rev 1 / Pol-Dependent},
  author={Yulia Pustovalova and Mariana T. Q. Magalh{\~a}es and Sanjay D’Souza and Alessandro A. Rizzo and George Korza and Graham C Walker and Dmitry M. Korzhnev},
  year={2016}
}
Translesion synthesis (TLS) is a mutagenic branch of cellular DNA damage tolerance that enables bypass replication over DNA lesions carried out by specialized low-fidelity DNA polymerases. The replicative bypass of most types of DNA damage is performed in a two-step process of Rev1/ Polζ-dependent TLS. In the first step, a Y-family TLS enzyme, typically Polη, Polι or Polκ, inserts a nucleotide across DNA lesion. In the second step, a four-subunit B-family DNA polymerase Polζ (Rev3/Rev7/PolD2… CONTINUE READING

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