Interaction between the MTHFR C677T polymorphism and alcohol--impact on oral cancer risk and multiple DNA methylation of tumor-related genes.

@article{Supi2011InteractionBT,
  title={Interaction between the MTHFR C677T polymorphism and alcohol--impact on oral cancer risk and multiple DNA methylation of tumor-related genes.},
  author={Gordana Supi{\'c} and Neboj{\vs}a Jovi{\'c} and Ru{\vz}ica Kozomara and Katarina Zeljic and Zvonko Magi{\'c}},
  journal={Journal of dental research},
  year={2011},
  volume={90 1},
  pages={65-70}
}
Several studies have reported Oral Squamous Cell Carcinoma (OSCC) association with etiological factors, such as smoking and alcohol. The aim of the present study was to establish whether the methylenetetrahydrofolate reductase (MTHFR) C677T genotype and a high alcohol intake, solely or in interaction, have an impact on the oral cancer risk, DNA methylation, or multiple methylation of tumor-related genes. MTHFR C677T genetic polymorphism was determined by the PCR/RFLP method, and DNA methylation… CONTINUE READING

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