Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus.

@article{Klannemark2000InteractionBT,
  title={Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus.},
  author={Mia Klannemark and Leena Suurinkeroinen and Marju Orho-Melander and Leif Groop and Marja Riitta Taskinen},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={2000},
  volume={17 8},
  pages={
          599-605
        }
}
AIMS Lipoprotein lipase (LPL) is a major regulator of triglyceride clearance. A genetic variant of the LPL gene on chromosome 8p22, Asn291Ser, has previously been associated with dyslipidaemia and an increased frequency of cardiovascular disease as well as familial disorders of lipoprotein metabolism. The aim of this study was to test whether the phenotypic expression of the LPL Asn291Ser variant is dependent upon glucose tolerance and insulin resistance. Therefore, the Asn291Ser variant was… CONTINUE READING