Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation.

@article{Furutani2007InteractionBT,
  title={Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation.},
  author={Yutaka Furutani and Hitomi Matsuno and Miwa Kawasaki and Takehiko Sasaki and Kensaku Mori and Yoshihiro Yoshihara},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 33},
  pages={8866-76}
}
Dendritic filopodia are long, thin, actin-rich, and dynamic protrusions that are thought to play a critical role as a precursor of spines during neural development. We reported previously that a telencephalon-specific cell adhesion molecule, telencephalin (TLCN) [intercellular adhesion molecule-5 (ICAM-5)], is highly expressed in dendritic filopodia, facilitates the filopodia formation, and slows spine maturation. Here we demonstrate that TLCN cytoplasmic region binds ERM (ezrin/radixin/moesin… CONTINUE READING