Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project

@article{Keers2011InteractionBS,
  title={Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project},
  author={Robert Keers and Rudolf Uher and Patricia Huezo-Diaz and Rebecca K. Smith and Sara R. Jaffee and Marcella Rietschel and Neven Henigsberg and Dejan Kozel and Ole Mors and Wolfgang Maier and A. Zobel and Joanna Hauser and Daniel Souery and Anna S Placentino and Erik R. Larsen and Monika Dmitrzak-Węglarz and Bhanu Gupta and Farzana Hoda and Ian W. Craig and Peter McGuffin and A. Elaine Farmer and Katherine J Aitchison},
  journal={The Pharmacogenomics Journal},
  year={2011},
  volume={11},
  pages={138-145}
}
There is substantial inter-individual variation in response to antidepressants, and genetic variation may, in part, explain these differences. For example, there is evidence to suggest that variation in the serotonin transporter gene (SLC6A4) predicts response to selective serotonin reuptake inhibitors (SSRIs). Environmental factors such as the occurrence of stressful life events before treatment may also be important. One prior report suggests that both factors interact in predicting response… CONTINUE READING

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