Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates.

@article{Barr2004InteractionBS,
  title={Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates.},
  author={Christina S. Barr and Timothy K Newman and Stephen G. Lindell and Courtney L. Shannon and Maribeth Champoux and Klaus-Peter Lesch and Stephen J. Suomi and David Goldman and James Dee Higley},
  journal={Archives of general psychiatry},
  year={2004},
  volume={61 11},
  pages={1146-52}
}
BACKGROUND Serotonin neurotransmission and limbic-hypothalamic-pituitary-adrenal (LHPA) axis hormones are thought to be involved in the reinforcement of alcohol intake and contribute to the risk for alcoholism. In humans and macaques, a promoter polymorphism that decreases transcription of the serotonin transporter gene is associated with anxiety and altered LHPA-axis responses to stress, and in female macaques, exposure to early-life stress alters LHPA-axis activation in response to alcohol… CONTINUE READING