Interaction between nonsteroidal anti-inflammatory drugs and high-dose methotrexate: a literature review.

  • Linda F Fischetti
  • Published 1990 in
    Journal of pediatric oncology nursing : official…


An important step in preventing methotrexate (MTX) toxicity is to assess patient self-medication of over-the-counter drugs before high-dose methotrexate (HD-MTX) treatment is administered. Nonsteroidal anti-inflammatory drugs given within a 10-day period before a patient receives HDMTX leads to a decreased MTX excretion rate causing MTX toxicity. Education… (More)


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