Interaction between nitric oxide and oxygen radicals in regulation of tubuloglomerular feedback.

@article{Wilcox2000InteractionBN,
  title={Interaction between nitric oxide and oxygen radicals in regulation of tubuloglomerular feedback.},
  author={Christopher Stuart Wilcox and William J. Welch},
  journal={Acta physiologica Scandinavica},
  year={2000},
  volume={168 1},
  pages={119-24}
}
NADPH oxidase, nitric oxide synthase (NOS) and cyclooxygenase are oxidases that are expressed in the juxtaglomerular apparatus (JGA) or blood vessels and can generate oxygen radicals (O-2) during partial reduction of molecular oxygen. O-2 interacts rapidly and irreversibly with nitric oxide (NO) to yield peroxynitrite (ONOO-), thereby restricting the half-life, diffusion distance and bioactivity of NO in tissues. NO generated by a neuronal (n) NOS isoform that is heavily expressed in macula… CONTINUE READING

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