Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: role in non-small cell lung cancer tumor proliferation.

@article{Wald2011InteractionBN,
  title={Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: role in non-small cell lung cancer tumor proliferation.},
  author={Ori Wald and Uzi Izhar and Gail Amir and Sophie Kirshberg and Zippora Shlomai and Gideon Zamir and Amnon Peled and Oz M. Shapira},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2011},
  volume={141 6},
  pages={1503-12}
}
OBJECTIVES Carcinoma-associated fibroblasts are reported to communicate microenvironment-derived signals through chemokine/chemokine receptor interaction, influencing carcinogenesis. We sought to characterize roles of CXCL12/CXCR4 in crosstalk between non-small cell lung cancer epithelial cell and carcinoma-associated fibroblasts and in tumor growth. METHODS Non-small cell lung cancer tumor samples obtained at surgery and from tumor arrays, as well as primary carcinoma-associated fibroblast… CONTINUE READING
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