Interaction between microtubule-associated protein tau and spectrin.

  title={Interaction between microtubule-associated protein tau and spectrin.},
  author={M F Carlier and Chuck Simon and R Cassoly and Lydie Pradel},
  volume={66 4},
Tau factor, one of the microtubule-associated proteins (MAPs), is shown here to bind to spectrin. Evidence for an interaction between these two proteins is provided by spectrin affinity chromatography of brain MAPs, gel overlay of electrophoresed MAPs with 125I-labelled spectrin, incorporation of tau factor in human erythrocyte ghosts, and demonstration that tau inhibits the F-actin cross-linking activity of tetrameric spectrin. The wide distribution of both tau and spectrin-like proteins in… CONTINUE READING
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