Interaction between metabotropic receptors and purinergic transmission in rat hippocampal slices

  title={Interaction between metabotropic receptors and purinergic transmission in rat hippocampal slices},
  author={Giacomo Casabona and M R L'episcopo and Patrizia Di Iorio and Renata Ciccarelli and Ernesto de Bernardis and H. Shinozaki and F. Nicoletti and Francesco Caciagli},
  journal={Brain Research},
Interactions between adenosine and metabotropic glutamate receptors in the rat hippocampal slice
Since the changes induced by metabotropic glutamate receptor agonists last for at least 60 min, the data imply that these interactions could play an important role in changes of synaptic function long after even transient increases of glutamate release in the CNS.
Trophic effects of purines in neurons and glial cells
Immortalized Hypothalamic Neurons Express Metabotropic Glutamate Receptors Positively Coupled to Cyclic AMP Formation
The results suggest that GT1‐7 cells express a novel mGluR subtype positively coupled to adenylate cyclase, which shares the same transduction pathway of other classical receptors coupled with a G,‐type of GTP‐binding protein.
Ontogenetic profile of ecto-ATPase activity in rat hippocampal and caudate nucleus synaptic plasma membrane fractions.
It is likely that ecto-ATPase, regulating the concentration of ATP and adenosine in synaptic cleft, has important role in the processes of brain development and aging.
Acute heat stress induces edema and nitric oxide synthase upregulation and down-regulates mRNA levels of the NMDAR1, NMDAR2A and NMDAR2B subunits in the rat hippocampus.
An increased production of NO as evident with upregulation of cNOS appears to be a key factor in the downregulation of NMDA receptor gene expression in heat stress.
The effects of passive avoidance learning on the release of amino acids and other putative transmitters in the forebrain of the day-old chick.
' 1 Chapter 1: Amino Acids as Neurotransmitters Introduction; 2 Chapter 2: Synaptic Plasticity, Learning and M emory, w ith reference to the Domestic Chick.
Determinants for further wishes for cosmetic and reconstructive interventions in 1652 patients with surgical treated carcinomas of the oral cavity
The wish for CRS depends on diverse functional psychosocial and psychological parameters and has to be issued during conversation to improve rehabilitation, and a decision on the medical treatment can be of greater satisfaction if the surgeon knows the patients’ needs and is able to compare them with the medical capabilities.


Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine
  • D. Winder, P. Conn
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1993
The hypothesis that 1S,3R- ACPD-stimulated increases in cAMP accumulation in rat hippocampal slices are dependent upon the presence of endogenous adenosine and are mediated by an mGluR that potentiates cAMP responses to other agonists is tested.
Activation of Metabotropic Glutamate Receptors in the Hippocampus Increases Cyclic AMP Accumulation
The results suggest that 1R,3S‐ACPD‐stimulated increases in cyclic AMP accumulation are not secondary to increases in cell firing or to activation of phosphoinositide hydrolysis, and that multiple metabotropic glutamate receptor subtypes exist, some of which are coupled to yet unidentified effector systems.
Is adenosine involved in inhibition of forskolin-stimulated cyclic AMP accumulation by caffeine in rat brain?
The results suggest that forskolin-stimulated cyclic AMP accumulation may be partially dependent on endogenousAdenosine but that the inhibition observed with caffeine is not solely due to blockade of adenosine receptors.
Endogenous Adenosine Regulates the Apparent Efficacy of 1‐Aminocyclopentyl‐1S,3R‐Dicarboxylate Inhibition of Forskolin‐Stimulated Cyclic AMP Accumulation in Rat Cerebral Cortical Slices
The results indicate that endogenous adenosine plays an important role in regulating the apparent efficacy of 1S,3R‐ACPD inhibition of forskolin‐stimulated cAMP accumulation in rat cerebral cortical slices and that previous studies in rat hippocampus and hypothalamus in the absence of added adenosin deaminase may have underestimated the efficacy of this compound.
Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation
The presence of a presynaptic glutamate receptor of the metabotropic type that mediates an enhancement of glutamate exocytosis in cerebrocortical nerve terminals is demonstrated and may have a physiological role in the maintenance of long-term potentiation.
Forskolin Stimulation of Cyclic AMP Accumulation in Rat Brain Cortex Slices Is Markedly Enhanced by Endogenous Adenosine
The data have been interpreted to indicate that the stimulation of cAMP accumulation in rat cortex slices by 1 μM F is predominantly due to synergistic interaction with endogenous adenosine and that the inhibition of this response by CAF is largely due to blockade ofAdenosine receptors.