Interaction between mannosylated lipoarabinomannan and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin influences dendritic cells maturation and T cell immunity.

@article{Wu2011InteractionBM,
  title={Interaction between mannosylated lipoarabinomannan and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin influences dendritic cells maturation and T cell immunity.},
  author={Tingting Wu and Shuliang Guo and Jianjun Wang and Lan Li and Lulu Xu and Ping Liu and Shuren Ma and Jie Zhang and Li Xu and Yongai Luo},
  journal={Cellular immunology},
  year={2011},
  volume={272 1},
  pages={94-101}
}
The aim of the study was to investigate the interaction between manLAM and DC-SIGN influencing DCs maturation and downstream immune response using small interfering RNA-expressing lentiviral vectors to specifically knockdown DC-SIGN. Our data indicated that DC-SIGN knockdown alone in DCs did not affect the maturation or the immunological function of lipopolysacharide (LPS)-activated DCs. Surface molecules were dramatically down-regulated in DCs primed with manLAM but not in mock control DCs (P… CONTINUE READING