Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.

  title={Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.},
  author={Jaewon Ko and Seho Kim and Juli G. Valtschanoff and Hyewon Shin and Jae-Ran Lee and Morgan Sheng and Richard T Premont and Richard J. Weinberg and Eunjoon Kim},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={23 5},
Liprin-alpha is a multidomain protein that interacts with the LAR family of receptor protein tyrosine phosphatases and the GRIP/ABP family of AMPA receptor-interacting proteins. Previous studies have indicated that liprin-alpha regulates the development of presynaptic active zones and that the association of liprin-alpha with GRIP is required for postsynaptic targeting of AMPA receptors. However, the underlying molecular mechanisms are not well understood. Here we report that liprin-alpha… CONTINUE READING


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