Interaction between ketoconazole and almotriptan in healthy volunteers.

  title={Interaction between ketoconazole and almotriptan in healthy volunteers.},
  author={Joseph C. Fleishaker and Beth D. Herman and Barbara J Carel and Nkechi E Azie},
  journal={Journal of clinical pharmacology},
  volume={43 4},
The interaction between almotriptan, a 5-HT1B/1D agonist, and the potent CYP3A4 inhibitor ketoconazole was examined in 16 healthy volunteers. Subjects received (A) 12.5 mg almotriptan orally on Day 2 of a 3-day regimen of 400 mg ketoconazole once daily and (B) 12.5 mg almotriptan in a crossover design. Plasma and urine concentrations of almotriptan were measured by HPLC. Treatment effects on almotriptan pharmacokinetics were assessed by analysis of variance. Ketoconazole coadministration… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…