Interaction between ketoconazole and almotriptan in healthy volunteers.

@article{Fleishaker2003InteractionBK,
  title={Interaction between ketoconazole and almotriptan in healthy volunteers.},
  author={Joseph C. Fleishaker and Beth D. Herman and Barbara J Carel and Nkechi E Azie},
  journal={Journal of clinical pharmacology},
  year={2003},
  volume={43 4},
  pages={423-7}
}
The interaction between almotriptan, a 5-HT1B/1D agonist, and the potent CYP3A4 inhibitor ketoconazole was examined in 16 healthy volunteers. Subjects received (A) 12.5 mg almotriptan orally on Day 2 of a 3-day regimen of 400 mg ketoconazole once daily and (B) 12.5 mg almotriptan in a crossover design. Plasma and urine concentrations of almotriptan were measured by HPLC. Treatment effects on almotriptan pharmacokinetics were assessed by analysis of variance. Ketoconazole coadministration… CONTINUE READING

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