Corpus ID: 33088825

Interaction between hyperthermia and oxygen radical formation in the 5-hydroxytryptaminergic response to a single methamphetamine administration.

@article{Fleckenstein1997InteractionBH,
  title={Interaction between hyperthermia and oxygen radical formation in the 5-hydroxytryptaminergic response to a single methamphetamine administration.},
  author={Annette E. Fleckenstein and Diana G. Wilkins and James W. Gibb and Glen R. Hanson},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 1},
  pages={
          281-5
        }
}
  • Annette E. Fleckenstein, Diana G. Wilkins, +1 author Glen R. Hanson
  • Published in
    The Journal of pharmacology…
    1997
  • Chemistry, Medicine
  • Administration of a single high dose of methamphetamine (METH) causes a rapid and reversible decrease in the activity of the tryptophan hydroxylase (TPH), the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine. This effect can be reversed completely by exposing the METH-impaired enzyme to a reducing environment, which suggests that the decrease in TPH activity is a reversible oxidative consequence of free radical formation. Consistent with this hypothesis, a single METH administration… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 38 CITATIONS

    Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism.

    VIEW 9 EXCERPTS
    CITES BACKGROUND & METHODS

    Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice

    VIEW 14 EXCERPTS
    CITES BACKGROUND & METHODS
    HIGHLY INFLUENCED

    Methamphetamine-induced rapid decrease in dopamine transporter function: role of dopamine and hyperthermia.

    VIEW 11 EXCERPTS
    CITES BACKGROUND & METHODS

    Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter.

    VIEW 4 EXCERPTS
    CITES RESULTS & BACKGROUND
    HIGHLY INFLUENCED

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 24 REFERENCES

    Improvements in the salicylate trapping method for measurement of hydroxyl radical levels in the brain

    • J. S. ALTHAUS, P. K. ANDRUS, E. D. HALL, P. F. VONVOIGTLANDER
    • In Central Nervous System Trauma: Research Techniques,
    • 1995
    VIEW 3 EXCERPTS
    HIGHLY INFLUENTIAL