Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors.

@article{Novinec2007InteractionBH,
  title={Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors.},
  author={Marko Novinec and Robert N. Grass and Wendelin J Stark and Vito Turk and Antonio Baici and Brigita Lenar{\vc}i{\vc}},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 11},
  pages={7893-902}
}
Proteolytic degradation of elastic fibers is associated with a broad spectrum of pathological conditions such as atherosclerosis and pulmonary emphysema. We have studied the interaction between elastins and human cysteine cathepsins K, L, and S, which are known to participate in elastinolytic activity in vivo. The enzymes showed distinctive preferences in degrading elastins from bovine neck ligament, aorta, and lung. Different susceptibility of these elastins to proteolysis was attributed to… CONTINUE READING

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