Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors.

@article{Liu2004InteractionBH,
  title={Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors.},
  author={Shuwen Liu and Gengfu Xiao and Yibang Chen and Yuxian He and Jinkui Niu and Carlos Escalante and Huabao Xiong and James G Farmar and Asim Kumar Debnath and P T Tien and Shibo Jiang},
  journal={Lancet},
  year={2004},
  volume={363 9413},
  pages={938-47}
}
BACKGROUND Studies on the fusion-inhibitory peptides derived from the heptad repeat 1 and 2 (HR1 and HR2) regions of the HIV-1 envelope glycoprotein gp41 provided crucial information on the viral fusogenic mechanism. We used a similar approach to study the fusogenic mechanism of severe-acute-respiratory-syndrome-associated coronavirus (SARS-CoV). METHODS We tested the inhibitory activity against infection of two sets of peptides corresponding to sequences of SARS-CoV spike protein HR1 and HR2… CONTINUE READING