Interaction between grapefruit juice and diazepam in humans

@article{zdemir1998InteractionBG,
  title={Interaction between grapefruit juice and diazepam in humans},
  author={Mehmet {\"O}zdemir and Y Aktan and B. S. Boydaĝ and Mustafa Cingi and A. Musmul},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={1998},
  volume={23},
  pages={55-59}
}
SummaryGrapefruit juice has been reported to markedly improve the bioavailability of triazolam, midazolam, terfenadine, cyclosporine and several dihydropyridine calcium channel blockers including felodipine, nifedipine, nitrendipine and nisoldipine. Because these drugs are metabolized by the hepatic cytochrome P450 isozyme (CYP) 3A4, the inhibitory effect of grapefruit juice is thought to results from inhibition of CYP3A4. In this study, our aim was to investigate the effects of grapefruit… CONTINUE READING

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