Interaction between granulosa-lutein cells and monocytes regulates secretion of angiogenic factors in vitro.

@article{Poe2011InteractionBG,
  title={Interaction between granulosa-lutein cells and monocytes regulates secretion of angiogenic factors in vitro.},
  author={Anna Połe{\'c} and Melinda R{\'a}ki and Thomas {\AA}byholm and Tom Tanbo and Peter Fedorcsak},
  journal={Human reproduction},
  year={2011},
  volume={26 10},
  pages={2819-29}
}
BACKGROUND Leukocyte infiltration and angiogenesis in the forming corpus luteum are prerequisites for normal ovarian function and may also underlie disorders like ovarian hyperstimulation syndrome. We examined whether ovarian angiogenesis could be affected by an interaction between granulosa-lutein (GL) cells and leukocytes. METHODS AND RESULTS We found that GL cells isolated from the follicular fluid synthesize and secrete the chemokine interleukin-8 (IL-8), which activates IL-8-receptor… CONTINUE READING

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