Interaction between granulin A and enolase 1 attenuates the migration and invasion of human hepatoma cells

Abstract

Granulin A (GRN A), a peptide with a molecular 6 kDa, is derived from proteolysis of progranulin (PGRN). Previous study in our laboratory has shown that GRN A is able to inhibit cancer cell growth significantly. In the present study, we confirmed that GRN A can bind to α-enolase (ENO1) specifically as analyzed using Pull-down/MS approaches. The interaction… (More)
DOI: 10.18632/oncotarget.16328

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