Interaction between glucose and free fatty acid metabolism in human skeletal muscle.

@article{Kelley1993InteractionBG,
  title={Interaction between glucose and free fatty acid metabolism in human skeletal muscle.},
  author={David E Kelley and Mari{\'a}n Mok{\'a}ň and J. A. Simoneau and Lawrence J. Mandarino},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 1},
  pages={91-8}
}
The mechanism by which FFA metabolism inhibits intracellular insulin-mediated muscle glucose metabolism in normal humans is unknown. We used the leg balance technique with muscle biopsies to determine how experimental maintenance of FFA during hyperinsulinemia alters muscle glucose uptake, oxidation, glycolysis, storage, pyruvate dehydrogenase (PDH), or glycogen synthase (GS). 10 healthy volunteers had two euglycemic insulin clamp experiments. On one occasion, FFA were maintained by lipid… CONTINUE READING

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