Interaction between glucocorticoids and β2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling

@article{Roth2002InteractionBG,
  title={Interaction between glucocorticoids and β2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling},
  author={Michael Roth and Peter A. Johnson and Jochen R{\"u}diger and Gregory G. King and Judith Lee Black},
  journal={The Lancet},
  year={2002},
  volume={360},
  pages={1293-1299}
}
BACKGROUND Increased airway smooth muscle bulk is a pathological feature of asthma. Asthma is well controlled by the combined inhalation of glucocorticoids and beta2-adrenoceptor agonists. The basic molecular mechanism of the interaction of the two drugs on proliferation of airway smooth muscle cells is yet to be identified. Our aim was to elucidate how glucocorticoids and beta2 agonists affect the growth of human bronchial airway smooth muscle cells. METHODS We assessed the effect of… CONTINUE READING
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