Interaction between fosamprenavir, with and without ritonavir, and nevirapine in human immunodeficiency virus-infected subjects.

@article{Dejesus2006InteractionBF,
  title={Interaction between fosamprenavir, with and without ritonavir, and nevirapine in human immunodeficiency virus-infected subjects.},
  author={Edwin Dejesus and Peter J. Piliero and Kim M. Summers and Mary Beth Wire and Daniel S. Stein and Amanda Masterman and Yu F Lou and Sherene S. Min and Mark J Shelton},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 9},
  pages={3157-9}
}
Fosamprenavir (FPV) with and without ritonavir (RTV) was added to the antiretroviral regimens of human immunodeficiency virus-infected subjects receiving nevirapine (NVP) to evaluate this drug interaction. Significant reductions in plasma amprenavir exposure (25 to 35%) were observed following coadministration of 1,400 mg of FPV twice a day (BID) and 200 mg of NVP BID. A regimen of 700 mg of FPV BID plus 100 mg of RTV BID may be coadministered with NVP without dose adjustment. 

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