Interaction between directional epistasis and average mutational effects.

@article{Wilke2001InteractionBD,
  title={Interaction between directional epistasis and average mutational effects.},
  author={Claus O. Wilke and Christoph Adami},
  journal={Proceedings. Biological sciences},
  year={2001},
  volume={268 1475},
  pages={1469-74}
}
We investigate the relationship between the average fitness decay due to single mutations and the strength of epistatic interactions in genetic sequences. We observe that epistatic interactions between mutations are correlated to the average fitness decay, both in RNA secondary structure prediction as well as in digital organisms replicating in silico. This correlation implies that, during adaptation, epistasis and average mutational effect cannot be optimized independently. In experiments with… CONTINUE READING

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