• Corpus ID: 42398899

Interaction between digoxin and commonly coadministered drugs in children.

  title={Interaction between digoxin and commonly coadministered drugs in children.},
  author={Gideon Koren},
  volume={75 6},
  • G. Koren
  • Published 1 June 1985
  • Medicine, Biology
  • Pediatrics
Quinidine and digoxin had been coadministered in cardiac patients for several decades before their interaction was reported in 1978. During the last few years, monitoring of increased digoxin serum concentration when several drugs are commonly coadministered with digoxin has led to reports of toxic accumulation of the cardiac glycoside. Because digoxin toxicity is frequently associated with severe morbidity and mortality, close monitoring of clinical and laboratory signs are mandatory whenever… 

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Clinical Pharmacokinetic Significance of the Renal Tubular Secretion of Digoxin

  • G. Koren
  • Biology, Medicine
    Clinical pharmacokinetics
  • 1987
Tubular secretion appears to be a major route of the renal elimination of digoxin and does not appear to be associated with the anionic or cationic transport systems, nor the Na+/K+-ATPase receptor.