Interaction between cyclosporine and grapefruit juice requires long-term ingestion in stable renal transplant recipients.

Abstract

STUDY OBJECTIVE To examine the effect of the concurrent administration of increasing amounts of grapefruit juice, an inhibitor of drug metabolism, on the steady-state pharmacokinetics of cyclosporine. DESIGN Open-label, three-period crossover, food-drug interaction study in stable renal transplant patients. SETTING A university-affiliated clinical… (More)

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