Interaction between chronic stress and clomipramine treatment in rats. Effects on exploratory activity, behavioral despair, and pituitary-adrenal function

@article{GarcaMarquez1987InteractionBC,
  title={Interaction between chronic stress and clomipramine treatment in rats. Effects on exploratory activity, behavioral despair, and pituitary-adrenal function},
  author={Cristina Garc{\'i}a-Marquez and Antonio Armario},
  journal={Psychopharmacology},
  year={1987},
  volume={93},
  pages={77-81}
}
The interaction between the effects of chronic electrical tail shock and clomipramine (CMI) on exploratory activity, behavioral despair and pituitary-adrenal function was studied in adult male rats. Both CMI and shock administered alone significantly reduced exploratory activity in a novel environment (holeboard). Neither interaction nor additive effects were observed when the two treatments were combined. In contrast, chronic shock increased the immobility in the forced swimming test… CONTINUE READING

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Problems with current catecholamine hypotheses of antidepressants agents: speculations leading to a new hypothesis

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