Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and genetic vulnerability to schizophrenia during explicit processing of aversive facial stimuli.

@article{Bianco2013InteractionBC,
  title={Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and genetic vulnerability to schizophrenia during explicit processing of aversive facial stimuli.},
  author={Luciana Lo Bianco and Giuseppe Blasi and Paolo Taurisano and Annabella Di Giorgio and Francesca Ferrante and Gianluca Ursini and Leonardo Fazio and Barbara Gelao and Raffaella Romano and Apostolos Papazacharias and Grazia Caforio and Lorenzo Sinibaldi and Teresa Popolizio and Cesario Bellantuono and Alessandro Bertolino},
  journal={Psychological medicine},
  year={2013},
  volume={43 2},
  pages={279-92}
}
BACKGROUND Emotion dysregulation is a key feature of schizophrenia, a brain disorder strongly associated with genetic risk and aberrant dopamine signalling. Dopamine is inactivated by catechol-O-methyltransferase (COMT), whose gene contains a functional polymorphism (COMT Val158Met) associated with differential activity of the enzyme and with brain physiology of emotion processing. The aim of the present study was to investigate whether genetic risk for schizophrenia and COMT Val158Met genotype… CONTINUE READING

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