Interaction between baseline and early worsening of renal function and efficacy of renin-angiotensin-aldosterone system blockade in patients with heart failure: insights from the Val-HeFT study.

@article{Lesogor2013InteractionBB,
  title={Interaction between baseline and early worsening of renal function and efficacy of renin-angiotensin-aldosterone system blockade in patients with heart failure: insights from the Val-HeFT study.},
  author={Anastasia Lesogor and Martin J. Cohn and Roberto C. Latini and Gianni Tognoni and Henry Krum and Barry Massie and Andrew James Zalewski and Albert Kandra and Tsushung Augie Hua and Claudio R. Gimpelewicz},
  journal={European journal of heart failure},
  year={2013},
  volume={15 11},
  pages={
          1236-44
        }
}
AIMS We evaluated the effect of (dual) renin-angiotensin-aldosterone system (RAAS) blockade with valsartan and an ACE inhibitor [92.7% of patients were treated with an ACE inhibitor in the Valsartan in Heart Failure Trial (Val-HeFT)] in patients with NYHA class II-IV heart failure (HF) and reduced EF on cardiovascular (CV) death and HF hospitalization by subgroups and by presence of early worsening of renal function (EWRF) and according to baseline estimated glomerular filtration rate (eGFR… CONTINUE READING
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