Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development

@inproceedings{Pettem2013InteractionBA,
  title={Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development},
  author={Katherine L. Pettem and Daisaku Yokomaku and Hideto Takahashi and Yuan Ge and Ann Marie Craig},
  booktitle={The Journal of cell biology},
  year={2013}
}
Rare variants in MDGAs (MAM domain-containing glycosylphosphatidylinositol anchors), including multiple protein-truncating deletions, are linked to autism and schizophrenia, but the function of these genes is poorly understood. Here, we show that MDGA1 and MDGA2 bound to neuroligin-2 inhibitory synapse-organizing protein, also implicated in neurodevelopmental disorders. MDGA1 inhibited the synapse-promoting activity of neuroligin-2, without altering neuroligin-2 surface trafficking, by… CONTINUE READING
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