Interaction between amyloid-beta (1-42) peptide and phospholipid bilayers: a molecular dynamics study.

@article{Davis2009InteractionBA,
  title={Interaction between amyloid-beta (1-42) peptide and phospholipid bilayers: a molecular dynamics study.},
  author={Charles H. Davis and Max L. Berkowitz},
  journal={Biophysical journal},
  year={2009},
  volume={96 3},
  pages={785-97}
}
The amyloid-beta (Abeta) peptide is a key aggregate species in Alzheimer's disease. Although important aspects of Abeta peptide aggregation are understood, the initial stage of aggregation from monomer to oligomer is still not clear. One potential mediator of this early aggregation process is interactions of Abeta with anionic cell membranes. We used unconstrained and umbrella sampling molecular dynamics simulations to investigate interactions between the 42-amino acid Abeta peptide and model… CONTINUE READING

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Paired b-sheet structure of an Ab(1–40) amyloid fibril revealed by electron microscopy

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