Interaction between allelic variation in IL12B and CCR5 affects the development of AIDS: IL12B/CCR5 interaction and HIV/AIDS.

@article{Gabutero2007InteractionBA,
  title={Interaction between allelic variation in IL12B and CCR5 affects the development of AIDS: IL12B/CCR5 interaction and HIV/AIDS.},
  author={Elwyn Gabutero and Corey L. Moore and Simon A Mallal and Graeme Andrew Stewart and Peter G. Williamson},
  journal={AIDS},
  year={2007},
  volume={21 1},
  pages={
          65-9
        }
}
OBJECTIVE IL-12 is involved in immune surveillance and response that links the innate and adaptive arms of the immune system. Among its many effects, IL-12 increases the cell surface expression of the CCR5 co-receptor for R5 strains of HIV-1, which are predominantly involved in HIV-1 transmission and spread. In the present study we investigated the effect of epistasis between allelic variants of CCR5 and IL12B on the susceptibility to HIV-1 infection and HIV-1 disease progression. METHODS HIV… CONTINUE READING
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